The region is classified as "hyper-arid", with typical annual rainfall of less than 3 centimetres (1.2 in).
Daily maximum temperatures average at 47 °C (117 °F) and can reach as high as 51 °C (124 °F). scorpions) and rodents, while plants live throughout the Empty Quarter.
On 25 February 2006, a scientific excursion organized by the Saudi Geological Survey began to explore the Empty Quarter.
The expedition consisted of 89 environmentalists, geologists and scientists from Saudi Arabia and abroad.
There is also evidence of human activity dating from 3,000 to 2,000 years ago, including chipped flint tools, but no actual human remains have been found.
The region has a hot desert climate typical of the larger Arabian Desert.
The desert covers some 650,000 square kilometres (250,000 sq mi) (the area of long. 16°30′−23°00′N) including parts of Saudi Arabia, Oman, the United Arab Emirates, and Yemen.
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In 2013 from 18 February to 28 March, South Korean explorer Young-Ho Nam led a team (Agustin Arroyo Bezanilla, Si-Woo Lee) on a crossing through the Empty Quarter on foot from Salalah, Oman, to Liwa Oasis, United Arab Emirates.
The crossing was performed with permission from the governments of Oman and UAE.